143. Sunscreen from Space? Delavie’s Kyle Landry Turns Space Microbes into Skincare

[00:00:00] GE - Kyle Landry - Kyle: extremophiles are amazing.

[00:00:02] GE - Kyle Landry - Kyle: They somehow can live in environments, that are detrimental to life and thrive and produce really cool compounds that are incredibly stable. that can be leveraged for so many different applications. And I love knowing, that chance of finding something brand new to science that no one else has ever discovered. Dr. Kyle Landry, we are so happy to have you on the Grow Everything Podcast.

[00:00:30] GE - Kyle Landry - Kyle: Thank you so much for having me. I'm so excited to be here.

[00:00:33] GE - Kyle Landry - Karl: Let's, do a little bit of background for our audience that doesn't know you. You've taken this really interesting journey from Extre profile of research to skin longevity, which is a really, , head turning unexpected journey. What first inspired you to go into the world of aging biology and when did you realize microbes might hold the key?

[00:00:55] GE - Kyle Landry - Kyle: So I'll start off by saying I never thought I'd be here. , I actually started off as a food scientist. so I went from food to longevity, to bio warfare, to diabetes drugs, to skincare is my exact journey. my extremophile journey started when I was doing my master's, , in food science. And I was actually looking for enzymes to make flavor nucleotides, which are certain pieces of genetic information that trigger umami taste in foods.

[00:01:25] GE - Kyle Landry - Kyle: It's a big, it's a big industry in food. Lot of people don't realize that's in there. So I was using extremophiles. To make potential novel food ingredients 'cause their enzymes work differently than some other ones. Longevity came in when I was finishing my PhD and someone by the name of David Sinclair gave me a phone call from Harvard Medical School and said, Hey Kyle, I read some of your papers.

[00:01:50] GE - Kyle Landry - Kyle: You're the only person I see doing this research. Do you wanna come, work in my lab for a little bit? So I went from having no longevity to all of a sudden working with like the longevity expert. , And that was my jump into the longevity space. But what's amazing is that extremophiles, dovetail nicely in longevity because somehow they've been able to survive and thrive in conditions that are normally detrimental to life. You may think, how does that link to longevity? Well, aging and diseases are just an accumulation of abuse over life. And if Extremophiles can do this at a hyperscale or hypersize, How can we leverage that and figure out how to work on our biology? And that was my direct connection into Longevity.

[00:02:40] GE - Kyle Landry - Kyle: Skincare came about, Plus years later, but I eventually made it there, but I never thought I'd be in skincare at all.

[00:02:47] GE - Kyle Landry - Erum: Wow. Yeah, there's just so much, longevity, extreme files, biotech space. It's just like everything's converging. And do pride ourselves on this podcast to be able to deconstruct some of this and then reconstruct it, , just like you have done in your career path. it's just all very exciting.

[00:03:05] GE - Kyle Landry - Erum: And I, love David Sinclair. I'm just wrapping up his book, lifespan. I'll put that in the show notes. it's a really good, , starter to really understand aging as a disease. so you are working with the brilliant minds on longevity and health, but you're also working with brilliant minds at space agencies.

[00:03:21] GE - Kyle Landry - Kyle: That's right.

[00:03:22] GE - Kyle Landry - Erum: how did working with space agencies shape the idea of delvy your company, and how did Astronaut Health turn into skincare?

[00:03:31] GE - Kyle Landry - Kyle: Yeah. so this is an interesting, crossroad here and I wanna step back for a second because. Normally like longevity research. It has an applied goal, but it's a long way to get there, to make it applied. Right now, the food industry is different. You have a short-term goal, sort of something that's applied, So somehow. I ended up in a space where we were developing technology that could be used in short to medium term that leveraged all of these things, which was amazing. So if we step back, with nasa, what happened was I was working with David on these EXTREMO files for these processes, and we discovered some really cool technology that could potentially have been used to clean the water systems on the International Space Station.

[00:04:17] GE - Kyle Landry - Kyle: And like I said, I was in the biodefense space in the first place, which is how we got into nasa. But we started testing, this technology, to clean the Mars Rover to clean the International Space Station. And then we also had a small molecule at the same time. That we actually won an award from NASA called the NASA iTech Award, and this award was based on a technology where, you could take this compound, it would upregulate your body's defenses in DNA repair mechanisms so that an astronaut could withstand and mitigate the effects of radiation on long duration space drought.

[00:04:53] GE - Kyle Landry - Kyle: We were already in space for that application. We're at the physical application of cleaning, disinfecting, removing debris, bacteria from the space station. And then while we're there, they were like, Hey, we have this organism that we're using to model sanitation disinfection. We put it outside the space station.

[00:05:12] GE - Kyle Landry - Kyle: It survived for 18 months, and now it has amazing resistance to UVC radiation. Now UVC we don't really care about unless you wanna disinfect your toothbrush or you're in a hospital and they disinfect the operating room with germicidal lamps, But the idea was can we extend this protection into UVA and UVB radiation, which is what we care about here for sun protection.

[00:05:36] GE - Kyle Landry - Kyle: so we took this test tube idea, brought it into our lab, and about a year and a half, two years of r and d, we were able to make something from this organism that could be added to sunscreens to enhance the sun protection value. And that's how Davy started because we figured no one's gonna buy an ingredient for sunscreen from a biological warfare company.

[00:05:59] GE - Kyle Landry - Karl: Right.

[00:06:00] GE - Kyle Landry - Kyle: And so we were like, we have to rebrand, reposition a little bit. So in 20 20, 20 21, we created Devy Sciences and that was our first step into skincare. But we later discovered a lot of longevity things that we ported over into other technologies as well.

[00:06:17] GE - Kyle Landry - Karl: That's amazing. I'm looking forward to getting into those and, diving deep into this, extremo file for sunscreen. But can you paint a picture of what it's like to experience one of your products? What's happening, on the surface, maybe on the molecular level when someone uses it. You mentioned UVC protection.

[00:06:37] GE - Kyle Landry - Karl: have you guys been able to add that UVA UV B protection into it?

[00:06:41] GE - Kyle Landry - Kyle: Yeah. Yeah. So, the r and d, we were able to figure out how to do that. And so now our ingredient, bacillus Legate is being sold around the world for sunscreens, where it enhances the U-V-A-U-V-B protection. You can get up to a 50 60% increase in SPF sun protection value. From this addition, we published.

[00:07:01] GE - Kyle Landry - Kyle: this in peer review journal so you can see how it works. , Now what's really interesting is that the organism itself produced this milky compound that coded itself. That's what protected it from this radiation, and that is not present in terrestrial versions of this organism. So you can find this, it's a ubiquitous organism, but it doesn't have.

[00:07:24] GE - Kyle Landry - Kyle: Properties that it developed from being in space and being in the conditions as before. So this is something that has evolved over time and we're able to leverage that for sun protection. Now on the longevity side. we were thinking, Hey, if this could survive and block radiation, it also must be able to repair itself.

[00:07:43] GE - Kyle Landry - Kyle: It must be able to protect itself. So David and I started tinkering with this, and this is where we discovered, it's activation of s sirtuin genes, which, if you're in the longevity space, you know what sirtuins are, DNA, repair, housekeeping, efficiency stuff with, mitochondria, all that stuff's in there.

[00:08:00] GE - Kyle Landry - Kyle: So it activates those. It also activates the pathways to increase your cell's ability to make hyaluronic acid. Now hyaluronic acid is added to almost every cosmetic skincare product,

[00:08:13] GE - Kyle Landry - Karl: Yeah, these days.

[00:08:14] GE - Kyle Landry - Kyle: but the problem is it may not absorb and penetrate in the skin, and even if it does, it's only there for a short period of time because it's not actually integrated into the matrix of your skin.

[00:08:25] GE - Kyle Landry - Kyle: The Bacillus plicate tells your body to make more. So you're having your own intrinsic hyaluronic acid, which is more efficacious and lasts longer than topical hyaluronic acid. outside of that you have free radical protection. So, UVA. leads to the formation of wrinkles. So if you step back, UVB leads to cancer, double strand breaks.

[00:08:48] GE - Kyle Landry - Kyle: Radiate UVA is what accelerates fine lines and wrinkles. And that's because UVA enters your skin, makes a free radical, and it cross links your collagen. Elastin higher breaks down all the components in your skin, which accelerates aging. So the bacillus lysate stops that from happening. Because it quenches or sequesters the free radicals that are formed from UVA.

[00:09:14] GE - Kyle Landry - Kyle: So you have a preventative wrinkle thing along with minimizing your current wrinkles 'cause of the hyaluronic acid. there's so many things that it does that we discovered that we're like, you know what, it does a lot more than just sunscreen for enhancing. So let's dive down that avenue as well.

[00:09:31] GE - Kyle Landry - Erum: I mean, this is something I als I also was thinking about in terms of collagen when people, just put collagen on their skin versus having it have your own body produce its own. Collagen is more effective.

[00:09:43] GE - Kyle Landry - Kyle: Yeah, of course.

[00:09:44] GE - Kyle Landry - Erum: and I wonder how many other molecules, that this process can, you can make these types of, molecules that are beneficial for yourself.

[00:09:51] GE - Kyle Landry - Erum: but it's really interesting because you're saying that this bacillus lysate on earth wasn't able to produce this, it was able to produce it in space only. So. When you brought it back down to Earth, how did it continue producing this? it sounds like evolved in these extreme environments, but then how did it turn into something that's gentle and restorative for skin?

[00:10:12] GE - Kyle Landry - Kyle: Yeah. So, that's the million dollar question, how, does anything evolve over time? but the in space, in Lower Earth orbit or Leo, um, genes are turned on that aren't necessarily turned on here on Earth because of three-dimensional physics, where , the genes touch each other and stuff like that.

[00:10:30] GE - Kyle Landry - Kyle: But, what we found is we were able to maintain that phenotype. By, growing it under certain conditions that allow those genes to continue to be expressed. So outside of just the organism, there is a proprietary way to grow at manufacturing process. All stuff we had to scale up and understand to make this a reality.

[00:10:51] GE - Kyle Landry - Kyle: I mean, we're selling hundreds of kilos of this stuff at a time. And so you can't make it in test tubes. So this is where now we went from a test tube to 5,000 to 15,000 liter reactors at a time. Yeah. So like outside of the RD we also had to have the scale up process of the economy. Industrial scale up. And that's one part. as scientists and researchers, I'll tell you, I never thought of or appreciated, like usually if you're a scientist or a graduate student, you're like, oh, I just care about this in the research area to get the paper out. But the feasibility of going from that to something that's works at economies of scale is, mind blowing, and you have to prepare for that and think about that.

[00:11:34] GE - Kyle Landry - Kyle: But yeah, it's crazy.

[00:11:36] GE - Kyle Landry - Karl: Can I just ask one question? you said that, and I'll summarize it, maybe I'm incorrect, you can correct me, that, NASA said, Hey, we've got this microbe that's been sitting outside of the Space Station. What did that look like? what do you mean it's sitting outside of the

[00:11:50] GE - Kyle Landry - Karl: Space Station?

[00:11:51] GE - Kyle Landry - Kyle: there's something called the Expose, which is a mod. I actually have pictures of it I could send you. expose is like a module that's attached to the Columbia space, lab part. It's basically like a box, where you can put all little samples and you can put all different filters on it, so you can expose it to like dark side of Mars, light side of Mars, dark side of moon, light side of moon or open space or all these different things, and it just sits out there.

[00:12:18] GE - Kyle Landry - Kyle: and then astronaut goes out there, collects the samples, brings it in, frees it, and sends it back down. So there's actually, implementation, partner modules that you can bolt on to do this type of research on the space station.

[00:12:31] GE - Kyle Landry - Erum: Yeah. Very cool. I mean, you're starting to sound like, two friends of the pod, Chris Mason and, Dr. Kate Rubins. have you met them?

[00:12:40] GE - Kyle Landry - Kyle: Yeah. Yeah. I've submitted grants with Chris Mason. , We actually had a grant, , I believe it was 2019, called Tri Omics in Space, where we were going to sequence. The astronauts genome in real time, send it down. Impact, look at the epigenetic drift and impacts of lower earth orbit on the astronauts sampling, saliva, feces, a whole bunch of other stuff.

[00:13:03] GE - Kyle Landry - Kyle: Yeah. So I know Chris Mason, we've submitted some grants together. talked about doing some research. Yeah,

[00:13:08] GE - Kyle Landry - Erum: That's incredible. Small world when it comes to astronaut genetics and mic extremophiles in space.

[00:13:16] GE - Kyle Landry - Kyle: I guess so.

[00:13:17] GE - Kyle Landry - Kyle: Yeah. That's incredible. and again, you mentioned David Sinclair at the top of the episode, one of the leading voices in longevity. We had a great portion of hearing him speak as well. it sounds like he obviously is influential.

[00:13:28] GE - Kyle Landry - Kyle: Is he part of the company right now?

[00:13:31] GE - Kyle Landry - Kyle: yeah. He co-founded De Lavy with myself, and he's all, he also co-founded the holding company. That de Lavy is part.

[00:13:38] GE - Kyle Landry - Erum: Do you see Devy expanding beyond skincare and what other industries might benefit from your discoveries? And I know that this question for entrepreneurs

[00:13:46] GE - Kyle Landry - Erum: but you know, you talked about other applications, so would love to vision you a little bit and hear from you.

[00:13:51] GE - Kyle Landry - Kyle: unfortunately we have to stay laser focused because we're in a crowded space. We're trying to make headway. We wanna, do something really well. But the applications outside could be for paint, could be for plastics, could be for fabric, could be for glass. This is just for the bacillus lysate, right?

[00:14:08] GE - Kyle Landry - Kyle: For uv. 'cause Affects a lot of things. I mean, plastics fade in yellow and crack paints fade over time. anything that could help protect this damage could be, this ingredient could be used for now. De Levy itself has. Over a thousand novel extremophiles that we use to create in mind for new ingredients.

[00:14:31] GE - Kyle Landry - Kyle: we just launched a new ingredient two months ago that comes from a thermophilic fungus, brand new genus of fungi there. And, that's used for cosmetics, for removing oil unplugging pores, controlling like the skin microbiome. But in reality, that could be used To clean and remove biofilms, pet food bowls or in the medical situation, you know, clean different surfaces,

[00:14:55] GE - Kyle Landry - Kyle: There's a lot of applications. in the other extre of files we have same thing. They can be applied for so many different things in the industrial, in consumer space, but we're constantly developing new ingredients, at least for consumer space and health and wellness right now. But there are other opportunities we do have.

[00:15:14] GE - Kyle Landry - Karl: it's so fascinating to me. we love that, extremophiles space because we feel like there's so much to learn there. But, you've worked with a thousand Extremophiles, what have you learned from them about resilience, either biologically or even personally?

[00:15:29] GE - Kyle Landry - Kyle: So I've worked with extre of files since 2009. so I've been in the extre of file space for quite some time, and they're very difficult to work with. One, they're not model organisms. Two, they grow in ridiculous conditions that sometimes are hard to reproduce. I'll give you an example. So the organism that we use to launch the ingredient a few months ago, it's called hydrolytic enzyme complex.

[00:15:54] GE - Kyle Landry - Kyle: When you do the traditional sequencing of proteomics or transcriptomics and you blasted NCBI, everything would be 30% similar. Which means it's related to nothing. And you have no information to do anything. So the common mindset of, oh, just sequence it. Oh, produce it in e coli goes out the window because you don't know what this is, you don't know what the function is.

[00:16:20] GE - Kyle Landry - Kyle: Even if you look at the active domains or like the main, like where you try to figure out what it does, it's not there. And then there are things called like ptms, post-translational modifications where. After the protein is made, some other machinery comes on and like bolts on a carbohydrate or something, right?

[00:16:38] GE - Kyle Landry - Kyle: You don't have that input like you would with an organism that's well studied. So it takes a lot longer to figure stuff out and you have to use a lot of old school biochem stuff that you know, from the sixties and seventies and eighties on how to purify things in the old school way. , But what I've learned is extremophiles are amazing.

[00:17:03] GE - Kyle Landry - Kyle: They somehow can live in environments, that are detrimental to life or would end life and thrive and produce really cool compounds that are incredibly stable. that can be leveraged for so many different applications. And I love knowing,that chance of finding something brand new to science that no one else has ever discovered.

[00:17:25] GE - Kyle Landry - Kyle: , And that just excites me. And that's why I've been in extreme of files for so long.

[00:17:30] GE - Kyle Landry - Erum: you have this fundamental knowledge. I mean, you're working with Extre Bowels for so long and there's so many different avenues that you can go down, but you're, you have this company, you're staying laser focused, very admirable. do you work with a university or research institute or maybe other entrepreneurs to be able to take your knowledge and share it with people that wanna apply what you've done?

[00:17:53] GE - Kyle Landry - Erum: I mean, scaling up in biotech has been very challenging for some people and you've, , figured out a pathway. How do you share, , this information with others that are trying to leverage biology?

[00:18:06] GE - Kyle Landry - Kyle: Yeah, so I'm very active in the mentoring community. So for example, I'm on the board of, the College of Natural Science, the Dean's board for UMass Amherst. I'm on the board of a few departments for some universities and I try to help. Students and people graduating think outside of, I just have to do this to check the box to graduate.

[00:18:27] GE - Kyle Landry - Kyle: It's more of how is this process teaching me or giving me tool sets to take it to the next level? to think about these large problems and, uh, understanding that in real life, you are working towards an end goal. You're not just doing something for, to do it. I found a lot of people in academia, graduate students and stuff, they don't think like that.

[00:18:50] GE - Kyle Landry - Kyle: They don't think of, how can I commercialize this? Or what can I make and go from there. They think of, oh, this is a cool science project. I wanna learn more. But in industry, it's not a race to learn as much as possible. It's a race to figure out how to make it a product as fast as possible and develop version 2.0 after version 1.0 is out.

[00:19:10] GE - Kyle Landry - Kyle: So I talk to a lot of people, mentor a lot of people. I have some people who are in the industry reach out and ask for insight. How can I do this? What can I do this? or they just like to hear the story that I tell sometimes and talk so they can be inspiring and be like, wow, like. I don't have to stay in this box.

[00:19:27] GE - Kyle Landry - Kyle: Right. That's another thing. People think like, wow, I am doing this. I have to stay in that box. That's my lane. I've never stayed in a box and I may be the minority. Honestly, like it, it doesn't always work out, but you don't have to think just because you did this, you have to stay in that for your whole life.

[00:19:45] GE - Kyle Landry - Kyle: see how the tools and skill sets you're learning can be applied to so many different. areas and then don't be afraid to step out of your box and see where it takes you.

[00:20:52] GE - Kyle Landry - Karl: Yeah, that's, I think that's really good advice and good to hear you saying it that way. It's interesting 'cause you guys sit at this like intersection of biology, beauty, longevity. Space science. It's like this convergence. You talked about how, you need to go back to like these old biochemistry techniques from the eighties, from the sixties, fifties, to be able to discover and understand how these, extremophiles work.

[00:21:19] GE - Kyle Landry - Karl: but do you see this work as being part of a larger shift in terms of like how we define health and resilience?

[00:21:25] GE - Kyle Landry - Kyle: Yeah, so I'm always, I've always thought about this way, and I don't wanna sound corny, like from. Jurassic Park, but nature will find a way. there's so many times where we try to discover or work on something, but there's already an answer out there in, in nature, right? So I think the mindset of longevity and health is going back down to fundamentals, like as simple as diet, exercise, sleep, getting that worked out, and then going to the next level.

[00:22:00] GE - Kyle Landry - Kyle: and people now are more intentional with what they do. They wanna know that the ingredients actually do stuff or work with stuff. they care about what they put on their body, what they put in their body, and having, transparency with information. What it can do is very important now. Now, where the ingredients come from is another matter, like people staying away from synthetics and GMO stuff like that, even though, that's a whole other debate on whether what that is.

[00:22:30] GE - Kyle Landry - Kyle: but just knowing that you can find something that's naturally occurring or comes from something from nature that can then be applied directly, really helps with the movement that people are,

[00:22:43] GE - Kyle Landry - Erum: Yeah. It's really interesting because, I asked, the question about, how do you share your information, your knowledge, because you had to build such fundamental maybe tools or processes in order to harness these extremophiles and, you know, having them produce molecules.

[00:22:57] GE - Kyle Landry - Erum: and you develop a product when, going straight for it. And there's always this, conversation when it comes to entrepreneurship, the platform versus product. And, we've been singing the praises of going, create a product and getting out there because you have this direct relationship with the people that are purchasing it.

[00:23:12] GE - Kyle Landry - Erum: Um, but. In your case, I'm like, a platform would be interesting because to be able to tame, you know, tame these or domesticate these extremo files, um, it seems to be like very valuable because just, you know, you shared all of these different applications. Um, and, and I don't know if you've ever, you know, given that thought, um, or if you wanted to share something because this is like a, a question that a lot of entrepreneurs are grappling with product versus platform.

[00:23:43] GE - Kyle Landry - Kyle: So we're doing both. Um, so we have, I'll say on the platform side, Davy side, where Davy Science's main goal is to be a technology powerhouse where we leverage these organisms. As platforms to create new ingredients, we then build products around those ingredients, right? So this allows us a unique opportunity because we see the benefits of these ingredients that we have from our r and d pipeline of innovation.

[00:24:14] GE - Kyle Landry - Kyle: And then we can say, wow, this ingredient fills this gap in the consumer good space, or in the industry space. Let's build a product around that. Um, so. It's actually very, very, uh. I don't wanna say nerve wracking, but there's a lot of stuff going on. Basically running two types of companies, right? An RD development company, uh, which is what we do here in Worcester with, I'm here in our lab.

[00:24:41] GE - Kyle Landry - Kyle: This is, you know, my office. We do all the r and d here. All the organisms create new things. But then we have the, in our case, the beauty arm, where we have a line which is all longevity skincare based on. The space ingredient, basc slice eight. And then we have a new cosmetic line coming out September October called layer one, which is based on that new ingredient I told you.

[00:25:03] GE - Kyle Landry - Kyle: Hydrolytic enzyme complex, it's face wash and toner. So we're kind of doing both and you know, I'm very lucky to be able to do that. But if I were to just, you know, not have this opportunity, you would have to figure out, you know. If you have the platform, are you just fundraising on the platform to get to the idea or do you wanna do a platform and launch one product to show you could do it?

[00:25:29] GE - Kyle Landry - Kyle: Because that's the other thing, right? A lot of people have ideas, but to actually do it, to go from A to Z to say, Hey, here's this crazy idea. Now I made a product and launched it. That's a different story than just pitching for ideas. Um, so you have to figure out, can I make a product? With the runway I have for financing to get it, to show that I can do it and then raise more money or, you know, go back and forth.

[00:25:56] GE - Kyle Landry - Kyle: And that is a big question. And it just depends on the product, the industry and, and what you're looking for.

[00:26:03] GE - Kyle Landry - Karl: Yeah, I was hoping, Kyle, you might talk about what it looks like on, you know, your corporate sponsor side, or corporate partner side is the way I should say it, because you guys are building these products, but you're already producing a lot of ingredients or a lot, can you talk a little bit like who's buying them?

[00:26:21] GE - Kyle Landry - Karl: You don't have to mention names. what kind, what kind of ingredients are they showing up in? Can, can we go out and buy

[00:26:27] GE - Kyle Landry - Karl: those

[00:26:27] GE - Kyle Landry - Karl: products

[00:26:28] GE - Kyle Landry - Kyle: Yeah, you can. You can go out. So the bacillus lysate inky name or the ingredient list is Bacillus Lysate, and it's available in various sunscreens that are sold domestically and internationally. It's also in some haircare products because UV radiation, bleaches dyed hair. So this is an example of we are in the longevity skincare space.

[00:26:51] GE - Kyle Landry - Kyle: We're not in the haircare space. So we can work with companies, sell them our ingredient to protect the hair from sun damage, which we never planned going into. That's great. And it's in some, uh, boutique shampoos and conditioners that are available in spas. Uh, we we're working with a group in out of the UK that's launching a whole line of lip care.

[00:27:14] GE - Kyle Landry - Kyle: And what they found was that because the bacillus lysate activates hyaluronic acid, it's great at plumping lips. Now we're not gonna make lipstick or lip balm 'cause we're in the longevity skincare space. So we work with them to formulate, they, they buy in green, they put it in their launching later this year with a whole new set of lines.

[00:27:36] GE - Kyle Landry - Kyle: Uh, we've worked with numerous formulation houses, large brands, large, massive conglomerates where they test our ingredient in various different products or our ingredients in different products. We're at various stages of products that have launched to just creation of ideas of products. Uh, so we're all over the place and that's a whole beast in itself.

[00:27:58] GE - Kyle Landry - Kyle: Outside of the Let's sell products on, you know, TikTok Meta in Instagram, D two C platform, Amazon, which is what we also do, which is a whole other, you know, crazy thing. And I'm split down the middle. So it's, uh, interesting times.

[00:28:16] GE - Kyle Landry - Erum: Oh my gosh. There's like so much we wanna talk. About offline when it comes to business. I think, I know Carl's, um, head gears are turning as, am I just from the companies that we know and speak with. Um, we could just see some, you know, nice partnerships happening on that side. And I think it's also because, um, you know, uh, we met at suppliers day and um, you know, you had a booth and you know, so in my mind I put you in the skincare bucket, but just.

[00:28:47] GE - Kyle Landry - Erum: The creation of other ingredients. Um, and you're using these microbes to create these ingredients. But these microbes aren't just the factory. Right. They're not actually going on your skin.

[00:28:58] GE - Kyle Landry - Kyle: Nope. They, they just make it so that. A lot of people ask, oh, is this a prebiotic or a probiotic? I'm like, no, It's not a probiotic where you're putting bacteria and stuff on there. it's bacteria that produces these things that normally would produce it to protect themselves, but yet it has the benefits of protecting us and we.

[00:29:20] GE - Kyle Landry - Kyle: Use them as a little factory to make it just like they make insulin and all these other compounds through, you know, production like that. And then we go from there.

[00:29:30] GE - Kyle Landry - Erum: compounds out, out, out, the production. And, um, but have you, I mean, I mean, maybe not for your company, but um. We've talked about, you know, the skin microbiome, uh, often on this podcast. And, um, you know, on one side there's been this, um, a lot of microbes that have been missing from our skin because we over clean, we live in these sterile environments.

[00:29:56] GE - Kyle Landry - Erum: Um. That come up in your research in terms of needing more microbes on our skin and especially in the context of astronauts they live. Probably I would at first, I would say in a very sterile environment when we're talking about the space station, but I heard that it's pretty much a pretty much a toilet up there.

[00:30:15] GE - Kyle Landry - Erum: So there's microbes all around,

[00:30:18] GE - Kyle Landry - Kyle: Yeah.

[00:30:18] GE - Kyle Landry - Erum: microbes on the.

[00:30:22] GE - Kyle Landry - Kyle: Yeah, so the skin microbiome is something, uh, I think is people don't put a lot of thought into until it's too late. So we've thought about this since the creation. Actually, all of our ingredients and products have been tested for the impact on their skin microbiome. So like the Bacillus lysate and the, the Hydrolytic enzyme Complex have been certified.

[00:30:44] GE - Kyle Landry - Kyle: By this German agency called My Microbiome, where they look at its impact on skin microbiome and controlling the, the levels of the bacteria. So we wanna make sure we don't disrupt the microbiome. 'cause if you do on the face, you get pimples boils, right? You get all these problems, dysbiosis that lead to negative effects.

[00:31:03] GE - Kyle Landry - Kyle: And the last thing I want and I believe in is to have, use more products. So like I'm anti 30 skews of skincare. I'm like. Two or three, and that's it. So we wanna make sure that what we're creating isn't harming any of that. Um, and yeah, I mean, there's a lot of evidence, whether it's for the gut, the gut brain axis, the skin, all these different things where diversity and microbiome balancing and not having dysbiosis is beneficial.

[00:31:35] GE - Kyle Landry - Kyle: and unfortunately using products or a lot of products can actually harm that and promote dysbiosis. how many people have used products and then all of a sudden break out? Yeah, it's plugged pores, all these other things, and that can lead to disbalance. So it's very important for us. So we make sure that our products and our ingredients do that.

[00:31:55] GE - Kyle Landry - Kyle: And that's actually the area of our research too. We're looking at ways to leverage these, either post biotic. Or prebiotics that these organisms can produce that actually enhance the already existing microbiome on the skin. Like that's a very interesting area and something that we're thinking about making products around because we're in this unique position where we can leverage these things that

[00:32:19] GE - Kyle Landry - Kyle: no one else

[00:32:19] GE - Kyle Landry - Erum: Yeah. I wonder what a world would be like if the bacillus lysate like lived on your skin. And then it's like, oops, you know, you're not selling products anymore, you're selling bacillus. It's

[00:32:33] GE - Kyle Landry - Erum: your skin. It's.

[00:32:36] GE - Kyle Landry - Kyle: Yeah. That, I mean, luckily means a version of bacillus. It's not the live thing, so there's nothing in there living. Um. But you know, if you travel a lot, this is a great example. If you travel a lot, your gut microbiome changes all the time based on what you eat, right? And it's the same thing if you go swimming in a pond or you change your soap, or you do this, you do that, you are change or, or you go move in with someone or you get a dog.

[00:33:04] GE - Kyle Landry - Kyle: All this stuff impacts all the time. Um, but it's just good to have an understanding to make sure you're not

[00:33:10] GE - Kyle Landry - Kyle: destroying it

[00:33:11] GE - Kyle Landry - Karl: totally. I'm curious, you know, Kyle, do you have like a point of view in terms of like, what does, you know, you, you guys are doing a lot of things in, in, uh, longevity and in skincare. What does skincare longevity look like in the next five or 10 years?

[00:33:26] GE - Kyle Landry - Kyle: I think it's going to be less masking and hiding. So a lot of products now temporary plump or hide or fill with silicone, right? They don't really address the issue. And the concept of longevity in skincare is relatively new. I mean, you just saw L'Oreal, CEO came out saying, Hey, we're focusing on this Estee Lauders fo focusing on that, right?

[00:33:48] GE - Kyle Landry - Kyle: Because they've realized. You know, skincare up until this point has just been hiding or masking or temporarily fixing, right? I mean, a great example is the in info, uh, info commercial where they put that stuff under the guy's eye and disappears in 10 seconds, but then like three hours later, his eyes come back, right?

[00:34:06] GE - Kyle Landry - Kyle: Because it's temporarily fixing it. So I think addressing the issues, trying to repair them and mitigating future damage. Is basically gonna be the direction and it's gonna be very tailored specific. I mean, everyone's microbiome's different. Everyone's skin is different in terms of oil versus dry the tone.

[00:34:30] GE - Kyle Landry - Kyle: but there'll be some basic underlying things that matter, like preventing from sun damage or preventing from environmental pollution to minimize accelerated aging, but then also addressing and repairing what's already been done. Now, honestly. You can't go back to what your skin was 20 years ago. It's impossible, but you can make it the best it can be at its current stage and then prevent future damage.

[00:34:55] GE - Kyle Landry - Kyle: And that's what we're trying to do at Daily View with our products. Like we're not saying your skin's gonna go back 20 years and you're gonna be like a baby, but we're saying, we'll make what you have right now the best it can be, and then sustain that for the future. and prevent against future damage instead of, playing will bring you back 30 years, which is

[00:35:13] GE - Kyle Landry - Kyle: impossible.

[00:35:14] GE - Kyle Landry - Erum: Yeah, that's the premium line that Kyle's been using. 'cause if you guys see him on the screen, he's actually 80 years old, so he has his premium line. He's working on that. He makes him look like, I don't know, he is like 20, 30 years old. I'm just kidding.

[00:35:28] GE - Kyle Landry - Erum: But

[00:35:28] GE - Kyle Landry - Kyle: no, I still have hair, which is surprising because I, I have three

[00:35:31] GE - Kyle Landry - Kyle: young

[00:35:32] GE - Kyle Landry - Erum: yeah. Oh

[00:35:34] GE - Kyle Landry - Kyle: surpris have my.

[00:35:35] GE - Kyle Landry - Erum: wow. Yeah, Carl too. He has three young, well, young anymore boys. So,

[00:35:41] GE - Kyle Landry - Karl: Yeah. Three young, young,

[00:35:43] GE - Kyle Landry - Karl: men.

[00:35:43] GE - Kyle Landry - Erum: young,

[00:35:43] GE - Kyle Landry - Erum: men.

[00:35:44] GE - Kyle Landry - Erum: Yeah. Um, you guys have three. Oh, wow. Can't imagine. Um, all right, so we're at the time where we do the quick fire question. So are you ready, Kyle?

[00:35:56] GE - Kyle Landry - Kyle: I am

[00:35:57] GE - Kyle Landry - Erum: You ready.

[00:35:58] GE - Kyle Landry - Erum: Okay. Okay. Um, I'll ask then, Carl, ask, okay. So here we go. Desert, deep sea, or space, where would you hunt for your next microbe?

[00:36:11] GE - Kyle Landry - Kyle: I've been to all of them already, so I would go back to

[00:36:17] GE - Kyle Landry - Kyle: Deep sea. I'd go back there. Or the arctic is where it actually.

[00:36:21] GE - Kyle Landry - Erum: Oh

[00:36:21] GE - Kyle Landry - Erum: snap. Awesome.

[00:36:23] GE - Kyle Landry - Karl: Yeah.

[00:36:24] GE - Kyle Landry - Kyle: But I've been to them already, unfortunately.

[00:36:28] GE - Kyle Landry - Karl: Uh, so what's a bio fact that most people don't believe, but they should believe it?

[00:36:33] GE - Kyle Landry - Kyle: Alright, so bio fact for longevity. everyone already has the tools and the know-how to extend your longevity, and that is getting a great night's sleep.

[00:36:43] GE - Kyle Landry - Kyle: A lot of hydration and controlling what you eat. You don't need a miracle pill. You don't need. Red light. You don't need coal plunges to do it. If you just work on those three foundations and then work on your mental health, you've already biohacked your way more than 99% of the population. If you can get those, you don't, you don't need something else

[00:37:06] GE - Kyle Landry - Kyle: to do it.

[00:37:07] GE - Kyle Landry - Erum: Yeah, you only need the phy sciences skincare line

[00:37:10] GE - Kyle Landry - Kyle: Yeah.

[00:37:11] GE - Kyle Landry - Erum: sure your skin

[00:37:12] GE - Kyle Landry - Kyle: Yeah, well that's skincare is a little different because that's protection and prevention from external elements. But in terms of feeling great, having great mental clarity, you know, really making your body optimal for function. I mean, you always know it. If you get a great night rest or you don't eat a lot of crappy food, or you don't drink a lot of alcohol, or you exercise, you feel great.

[00:37:35] GE - Kyle Landry - Karl: Yeah.

[00:37:35] GE - Kyle Landry - Kyle: not do that every day?

[00:37:36] GE - Kyle Landry - Erum: Yeah. Love it. Um, okay, so what's your personal skincare non-negotiable?

[00:37:44] GE - Kyle Landry - Kyle: Actually, it's the daily sign serum. That's the non-negotiable. And so I'll tell you a thing, I've never used skincare in my life until I started here. I saw the clinical data and I was blown away. So I started using it, and honestly, I've never. I've never gone back. I use other face washes and stuff, like I'll use Cetaphil for example, which is a great face wash.

[00:38:11] GE - Kyle Landry - Kyle: Very simple. Um, but our new face wash coming out's better than that in my opinion, but we'll see what happens, what the people think. But I would say our serum and then sunscreen of course, um, sunscreen, people get a lot of. Misinformation about, uh, the biggest thing I'll say about sunscreen is pay attention to the directions for use.

[00:38:32] GE - Kyle Landry - Kyle: And I'll give you a great example. My daughters, we, we buy like the giant spray cans that you spray on, and if you read it, it says there are four applications per can.

[00:38:44] GE - Kyle Landry - Kyle: How many, how many times do you actually use that can? Weeks and weeks and weeks, right? So this misinformation where sunscreen may not be working or people question it's used could be 'cause they're just not following directions.

[00:38:57] GE - Kyle Landry - Kyle: So you have to follow the direction, see how much you're putting on, follow the, the reapplication, uh, because all of those things dictate its SPF value. You can't assume that if you put it on one to 8:00 AM you're good all day.

[00:39:11] GE - Kyle Landry - Karl: Yeah.

[00:39:11] GE - Kyle Landry - Kyle: Unfortunately that's what that population does.

[00:39:14] GE - Kyle Landry - Karl: Yeah, that's what most people do. It's

[00:39:15] GE - Kyle Landry - Kyle: yeah, yeah, yeah. So you gotta follow the directions for skincare, uh, in sun care because all the claims, the data, the protection, are all based on those directions that are on the bottom.

[00:39:28] GE - Kyle Landry - Karl: So we, uh, continuing with the quick fire, would you rather discover a microbe that halts aging or reverses aging?

[00:39:35] GE - Kyle Landry - Kyle: Halts aging, a hundred percent halts aging. Um. Because, uh, reversing aging, I just don't, I just don't know if what that would do. I think halting it in your prime now, it would be ideal. Now socially, who knows what that will do? Social economics and population and all of that. But all that aside, I think halting aging, um, would, would be very interesting in my mind.

[00:40:07] GE - Kyle Landry - Erum: Yeah. Yeah. Okay. Final question. The weirdest place you've collected a sample from.

[00:40:15] GE - Kyle Landry - Kyle: The weirdest place was my grandmother's air conditioner. So in the back I took apart her air conditioner, and in the back there was this really dark, black, disgusting slime. So I took samples from there. I think we got 15 organisms from there. Another thing I'll tell you, I'll tell you two of two other ones a can of petroleum jelly from 1950s.

[00:40:44] GE - Kyle Landry - Kyle: From the 1950s. So I found this in a supply closet. Uh, where I was and they were gonna throw it out, whereas I was at school, they put it, they, they were like, oh, that's old. We don't want, I took it and we isolated two organisms from that, from in the middle of the petroleum jelly from the night. I still have the can in the lab actually, 'cause it looks pretty cool.

[00:41:05] GE - Kyle Landry - Kyle: And then the third one, um, was underground when I went 5,000 feet underground in a gold mine. That was, that was a phenomenal place to go.

[00:41:14] GE - Kyle Landry - Erum: Wow. What did you find? It. Like, does anything like, do these microbes do anything crazy? Like are they named after you because they didn't exist before? Like what?

[00:41:26] GE - Kyle Landry - Kyle: There's a lot of cool things. Uh, the one from the mine we're looking at, um, as an ingredient because it helps protect from, uh, heavy oxidation from iron and a few other things that are pro agent pro oxidants. Um, we have a bunch of unknown named organisms. Um, that's actually something we have to deal with, and that's like writing papers, showing what they are claiming names.

[00:41:52] GE - Kyle Landry - Kyle: So like the organism that makes our ingredient for the face wash. We actually name that. It's called Alium. Thermos Staus. It's a brand new genus. Fungi, we had to go through the whole process of naming it, submitting it to a collection, publishing it, and CPI, this whole other thing. And that's a whole RD project in itself. So, uh, yeah, there, there's a lot of cool things going on here, but unfortunately not enough time to do everything.

[00:42:19] GE - Kyle Landry - Karl: Yeah, it's true. Um, I don't know, Kyle, I mean, I feel like we could talk for a really long time, but, um, we do have to wrap up this interview. Um, you know, we really appreciate you coming on. I think we've got a lot to talk

[00:42:33] GE - Kyle Landry - Karl: about for

[00:42:35] GE - Kyle Landry - Kyle: Yeah, anytime. If you have any other questions about anything, food, nutrition, skincare, biotech, space, just just let me know.

[00:42:43] GE - Kyle Landry - Erum: Yeah, absolutely. Thanks again for coming on the Grab Everything podcast. Um, it's been incredible and of course.

[00:42:51] GE - Kyle Landry - Kyle: Thank you so much.

[00:42:53] GE - Kyle Landry - Karl: Enjoy the rest of your day.